DOSAGE AND ADMINISTRATION 2.1 Important Dosage and Administration Instructions 2.2 Recommended Dosage in Adults 2.3 Recommended Dosage in Pediatric Patients including Neonates 2.4 Concomitant or Pre-Administration of Anticholinergic Agents

----------------------DOSAGE AND ADMINISTRATION----------------------Dosage  Should be administered by trained healthcare providers (2.1)  Recommend use of a peripheral nerve stimulator to determine whether neostigmine methylsulfate should be administered and to monitor recovery from neuromuscular blockade (2.1).  Recommended dosage range is 0.03 mg/kg to 0.07 mg/kg for reversing non-depolarizing neuromuscular block when administered with an anticholinergic agent (atropine or glycopyrrolate) (2.2, 2.3, 2.4) o For reversal of NMBAs with shorter half-lives, when first twitch response is substantially greater than 10% of baseline, or when a second twitch is present: 0.03 mg/kg by intravenous route (2.2) o For reversal of NMBAs with longer half-lives or when first twitch response is close to 10% of baseline: 0.07 mg/kg by intravenous route (2.2)  Maximum total dosage is 0.07 mg/kg or up to a total of 5 mg (whichever is less) (2.2)  An anticholinergic agent, e.g., atropine sulfate or glycopyrrolate, should be administered prior to or concomitantly with neostigmine methylsulfate (2.4)